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[
Curr Biol,
1994]
Two genes that control dauer formation in the soil nematode Caenorhabditis elegans have direct effects on senescence.
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[
Med Trop (Mars),
1998]
Two methods are being used to control onchocerciasis. The first has a delayed effect and consists in reducing or interrupting transmission of Onchocerca volvulus by eradication of the vector at its most vulnerable developmental stage, i.e. the larval stage. The second method has more immediate effects and consists in mass treatment using ivermectin, the only widely available drug, to reduce the density of microfilariae (the pathogenic stage of the parasite) in the population. Both strategies have been implemented within the framework of two international programs: the Onchocerciasis Control Program (OCP) in West Africa, which started in 1974 and will continue until the end of 2002, and the African Program for Onchocerciasis Control (APOC), which was launched in 1995 and will last for 12 years. This article presents an overview of the efficacy of available control tools, as well as the objectives, strategies, organization, and results of the two ongoing control programs. Also dealt with are future perspectives of onchocerciasis control including monitoring techniques to maintain OCP gains, and research to develop new control tools and optimize the program efficacy.
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[
Sci Robot,
2021]
Analysis of <i>Caenorhabditis elegans</i> natural movement and optogenetic control of its muscle cells enable controlled locomotion.
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[
WormBook,
2005]
Early development of many species depends on the temporal and spatial control of maternal gene products. This review discusses the control of maternal mRNAs that encode regulators of C. elegans embryogenesis. In the C. elegans embryo, maternal mRNA regulation is crucial to the patterning of early cell fates. Translational control of key mRNAs spatially organizes cell signaling pathways, localizes transcription factor activities, and controls germ cell precursor development. From the few mRNAs studied thus far, some themes are beginning to emerge. Control of maternal mRNA translation begins in the hermaphrodite germ line. Distinct regulatory systems keep mRNAs silent during different stages of oogenesis, and lead to precise temporal and spatial patterns of translation in the embryo. In the embryo, cell polarity factors control the localization of translational regulators. Each maternal mRNA contains multiple elements in its 3'' untranslated region (3'' UTR) that specify the timing and localization of translation. A relatively small number of RNA-binding proteins likely control many mRNAs through these 3'' UTR elements. Therefore, the combination of RNA elements and the regulatory complexes recruited to them specify unique patterns of translation for different mRNAs. The mechanisms of translational control are only beginning to be explored, but are likely to regulate diverse developmental and cellular events in metazoans.
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[
Philos Trans R Soc Lond B Biol Sci,
2018]
Control is essential to the functioning of any neural system. Indeed, under healthy conditions the brain must be able to continuously maintain a tight functional control between the system's inputs and outputs. One may therefore hypothesize that the brain's wiring is predetermined by the need to maintain control across multiple scales, maintaining the stability of key internal variables, and producing behaviour in response to environmental cues. Recent advances in network control have offered a powerful mathematical framework to explore the structure-function relationship in complex biological, social and technological networks, and are beginning to yield important and precise insights on neuronal systems. The network control paradigm promises a predictive, quantitative framework to unite the distinct datasets necessary to fully describe a nervous system, and provide mechanistic explanations for the observed structure and function relationships. Here, we provide a thorough review of the network control framework as applied to <i>Caenorhabditis elegans</i> (Yan <i>et al.</i> 2017 <i>Nature</i><b>550</b>, 519-523. (doi:10.1038/nature24056)), in the style of Frequently Asked Questions. We present the theoretical, computational and experimental aspects of network control, and discuss its current capabilities and limitations, together with the next likely advances and improvements. We further present the Python code to enable exploration of control principles in a manner specific to this prototypical organism.This article is part of a discussion meeting issue 'Connectome to behaviour: modelling <i>C. elegans</i> at cellular resolution'.
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[
Philos Trans R Soc Lond B Biol Sci,
1985]
The genetic control of cell lineage has been studied extensively in Caenorhabditis elegans. In this paper, three studies of cell lineage mutants are reviewed: the isolation of mutations affecting vulval cell lineages, and the analysis of two 'control genes',
lin-12 and
lin-14. In addition, certain logical features of the genetic programme, as inferred from or illuminated by the study of cell lineage mutants, are discussed: the concepts of 'control genes' and developmental subprogrammes, and the organization of the lineage into a hierarchy of binary
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[
Trends in Genetics,
1985]
Sexual phenotype in Caenorhabditis elegans is determined by a small number of control genes which are organized in a cascade of regulatory interactions.
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[
Nat Rev Genet,
2003]
Many crucial decisions, such as the location and timing of cell division, cell-fate determination, and embryonic axes establishment, are made in the early embryo, a time in development when there is often little or no transcription. For this reason, the control of variation in gene expression in the early embryo often relies on post-transcriptional control of maternal genes. Although the early embryo is rife with translational control, controlling mRNA activity is also important in other developmental processes, such as stem-cell proliferation, sex determination, neurogenesis and erythropoiesis.
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Prog Mol Biol Transl Sci,
2009]
Translational control of specific messenger RNAs, which themselves are often asymmetrically localized within the cytoplasm of a cell, underlies many events in germline development, and in embryonic axis specification. This comprehensive, but by no means exhaustive, review attempts to present a picture of the present state of knowledge about mechanisms underlying mRNA localization and translational control of specific mRNAs that are mediated by trans-acting protein factors. While RNA localization and translational control are widespread in evolution and have been studied in many experimental systems, this article will focus mainly on three particularly well-characterized systems: Drosophila, Caenorhabditis elegans, and Xenopus. In keeping with the overall theme of this volume, instances in which translational control factors have been linked to human disease states will also be discussed.
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[
Acta Trop,
2020]
This review summarises more than a century of research on onchocerciasis, also known as river blindness, and its control. River blindness is an infection caused by the tissue filaria Onchocerca volvulus affecting the skin, subcutaneous tissue and eyes and leading to blindness in a minority of infected persons. The parasite is transmitted by its intermediate hosts Simulium spp. which breed in rivers. Featured are history and milestones in onchocerciasis research and control, state-of-the-art data on the parasite, its endobacteria Wolbachia, on the vectors, previous and current prevalence of the infection, its diagnostics, the interaction between the parasite and its host, immune responses and the pathology of onchocerciasis. Detailed information is documented on the time course of control programmes in the afflicted countries in Africa and the Americas, a long road from previous programmes to current successes in control of the transmission of this infectious disease. By development, adjustment and optimization of the control measures, transmission by the vector has been interrupted in foci of countries in the Americas, in Uganda, in Sudan and elsewhere, followed by onchocerciasis eliminations. The current state and future perspectives for control, elimination and eradication within the next 20-30 years are described and discussed. This review contributes to a deeper comprehension of this disease by a tissue-dwelling filaria and it will be helpful in efforts to control and eliminate other filarial infections.