[
2006]
Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. This book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer's, schizophrenia, and ADHD.
[
2006]
Bringing together the latest information into one easily accessible resource, The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology explores the diverse tools and technologies used to study synaptic processes. Written by world-renowned leaders in the field, the book delineates newly developed techniques, methods, and conceptual advances used for studying neurotransmitter receptors and other synaptic proteins. A broad array of molecular, biochemical, imaging, and electrophysiological approaches for studying the biology of synapses are described. Specific topics include the use of proteomics to study synaptic protein complexes, the development of phosphorylation state-specific antibodies, post-genomic tools applied to the study of synapses, and RNA interference in neurons. In addition, several chapters focus on methods for gene and protein delivery into neuronal tissue. The use of biochemical, electrophysiological, and optical tagging techniques to study the movement and membrane trafficking of neurotransmitter receptors in the membranes of live nerve cells are also discussed. To complement these approaches, the application of state-of-the-art approaches for achieving long-term alterations in the genetic complement of neurons in vivo using viral vectors or homologous recombinations of ES cells is also described.