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Cell Cycle,
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Comment on: Banerjee D, et al. Cell Cycle 2010; 9:4748-65.
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Nature,
1994]
On page 32 of this issue, a joint team from the Genome Sequencing Center (St. Louis, USA) and the newly founded Sanger Centre (Hinxton Hall, Cambridge, UK) report a contiguous sequence of over two megabases from chromosome III of the nematode worm, Caenorhabditis elegans. This is the longest contiguous DNA sequence yet determined, and it prompts rumination on how far we have come in the sequencing enterprise, and on how far - and where - we have
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[
Genome,
1989]
Eight speakers described current research on the small nematode Caenorhabditis elegans, a popular model for the genetic analyis of animal development and behavior.
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Nature,
1997]
Who scapes the lurking sepent's mortal sting? Not he that sets his foot upon her back. Even the smallest of worms will turn, when trodden on.
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Science,
1998]
The near completion of the sequence of the C. elegans genome should provide researchers with a gold mine of information on topics ranging from evolution to gene
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Nat Neurosci,
2000]
A recent Nature paper on mice lacking the Na+ channel BNC1 shows that this channel is essential for neuronal touch receptor function and may be part of a mechanosensory complex.
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Nature,
2002]
Behavioral ecologists have shown that many animals form social groups in conditions. Neurobiological evidence for this behaviour has now been discovered in the nematode worm, Caenorhabditis elegans. On pages 899 and 925 of this issue, de Bono et al. and Coates and de Bono present striking results on the genetic, molecular and neural mechanisms underlying nematode social feeding. These discoveries provide tantalizing insights into the effects of stress in social groupings.
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BMB Rep,
2015]
Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms ranging from simple invertebrates to mammals including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe mechanisms by which various IIS components regulate aging in C. elegans and D. melanogaster. We also cover systemic and tissue-specific effects of the IIS components on the regulation of lifespan. We further discuss IIS-mediated physiological processes other than aging and its effects on human disease models focusing on findings that used C. elegans. As both C. elegans and D. melanogaster have been essential for key findings regarding the effects of IIS on organismal aging in general, these invertebrate models will continue to serve as workhorses to help our understanding of mammalian aging.
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[
The Journal of NIH Research,
1991]
Cowabugna, dudes! Those lean, gene-revealing machines have scored a most totally excellent victory in the battle to understand aging. We are, of course, talking about mutant ninja nematodes here. At a conference on aging in January at Cold Spring Harbor's Banbury Center, Thomas Johnson of the Institute for Behavioral Genetics at the University of Colorado in Boulder brought some dudes and dudettes from Capitol Hill up to date on the latest awesome achievements of the bodacious beasts know as Caenorhabditis elegans.
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Nature,
1999]
Once, lifespan genetics was largely the domain of theorists, who tried to explain why an organism's genes so cavalierly allow individual somas to die. But a flood of papers on the nematode worm Caenorhabditis elegans has brought the subject into the realm of serious experimental analysis. The latest studies (1,2), including a report by Apfeld and Kenyon (1) on page 804 of this issue, indicate that the nervous system has a key function in regulating lifespan. Perhaps we are, indeed, only as old as we think