Harris JM, Maloof JN, Kenyon CJ, Salser SJ, Mueller-Immergluck MM, Honigberg LA, Cowing DW, Waring DA, Costa M, Wang BB, Wrischnik LA, Hunter CP, Austin JA
[
Cold Spring Harb Symp Quant Biol,
1997]
Hox mutations are fascinating. Like magic, they can turn antennae into legs or create extra wings. What makes these genes so talented? How can they make such high-level decisions? Are there simple rules that can explain the effects they have on the development of individual cells? Do the genes act multiple times during the development of a tissue to micromanage individual cell fate decisions, or can they act relatively early to initiate developmental programs that run independently of their further input?