A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage.
daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.AD - Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.FAU - Kimura, K DAU - Kimura KDFAU - Tissenbaum, H AAU - Tissenbaum HAFAU - Liu, YAU - Liu YFAU - Ruvkun, GAU - Ruvkun GLA - engSI - GENBANK/AF012437ID - RO1AG14161/AG/NIAPT - Journal ArticleCY - UNITED STATESTA - ScienceJID - 0404511RN - 0 (DAF-2 protein)RN - 0 (Phosphatidylinositol Phosphates)RN - 0 (insulin receptor-related receptor)RN - 0 (phosphatidylinositol 3,4,5-triphosphate)RN - 11061-68-0 (Insulin)RN - 50-99-7 (Glucose)RN - EC 2.7.1 (Phosphotransferases (Alcohol Group Acceptor))RN - EC 2.7.1.137 (1-Phosphatidylinositol 3-Kinase)RN - EC 2.7.11.- (Receptor, IGF Type 1)RN - EC 2.7.11.- (Receptor, Insulin)SB - IM