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[
Neuron,
2018]
While PIWI-interacting RNAs (piRNAs) are primarily recognized as guardians of genome integrity, new functions of these small non-coding RNAs are emerging. In this issue, Kim etal. (2018) describe a piRNA-based mechanism that limits axon regeneration in C.elegans.
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[
Cell Host Microbe,
2022]
Caenorhabditis elegans do not grow on either Staphylococcus saprophyticus or heat-killed Escherichia coli, but do so when exposed to both. In this issue of Cell Host & Microbe, Geng and colleagues have identified E.coli-derived signals as well as the host's neural and innate immunity pathways that promote digestion of S.saprophyticus.
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[
Nematologica,
1977]
SEM observations of adult Caenorhabditis briggsae females showed differences between young and old nematodes. In young nematodes the cuticle was generally smooth, whereas in old ones it was wrinkled. Deirids were located at the level of the excretory pore in the lateral field. They were distinct in young nematodes but indistinct in old ones. The oral opening was formed by six lips, which were closed in old nematodes and open in young ones. The vulva possessed two semi-circular lips and was bordered by two lateral flaps. These lips were smooth in young specimens and wrinkled in old ones. Cryofractures of old nematodes showed cavities in the intestinal epithelium corresponding to areas in which age pigment granules normally occur. No such cavities were seen in young nematodes.
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[
Elife,
2019]
Young <i>Caenorhabditis elegans</i> hermaphrodites use their own sperm to protect against the negative consequences of mating.
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[
Nat Methods,
2008]
We describe an automated method to isolate mutant Caenorhabditis elegans that do not appropriately execute cellular differentiation programs. We used a fluorescence-activated sorting mechanism implemented in the COPAS Biosort machine to isolate mutants with subtle alterations in the cellular specificity of GFP expression. This methodology is considerably more efficient than comparable manual screens and enabled us to isolate mutants in which dopamine neurons do not differentiate appropriately.
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[
Kisaengchunghak Chapchi,
1966]
The clinical manifestations in filarial infection were examined during 1965-1966 from the known endemic areas: Yongju, a mountainous inland area and Cheju-Do, an island. 1. All the microfilaria which were found during the survey were Brugia malayi. 2. The principal symptom was cuticular hypertrophy (elephantiasis). It was found in 4 cases from Yongju among 707 villagers, 84 cases from Cheju-Do among 2,376 villagers. 3. Four microfilaremia cases (4.5%) were found among a total of 88 cases of elephantiasis. 4. In Cheju-Do, the higher incidence of elephantiasis was observed among people over 20 years old and the females showed much higher incidence than males (30 males and 54 females). 5. The cuticular hypertrophic changes (elephantiasis) appeared more often in the lower extremities(77%) than in the upper part of the body, and in the right side than in the left.
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[
Journal of Nematology,
1972]
The specific gravity of old Caenorhabditis briggsae was shown to be greater than that of young nematodes. The possible explanations for this age-associated change are discussed.
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[
Cold Spring Harb Symp Quant Biol,
1982]
Microtubules (MTs) are ubiquitous components of neuronal processes, and although they have been implicated in neurite outgrowth, shape maintenance, axonal transport, and sensory transduction, their function remains unclear. The MTs in the neurons of the nematode Caenorhabditis elegans have unusual structures that permit a comparative approach to the relationship of microtubule structure and function. A set of six touch-receptor neurons (the microtubule cells) contain prominent arrays of large MTs. These MTs have more protofilaments than do MTs in other neurons (15 as opposed to 11), and they respond differently to antimicrotubule drugs, fixation protocols, temperature, and mutation. Studies of C. elegans neurotubules suggest that most MT functions do not require long, continuous MTs or MTs with a specific number of protofilaments. Some functions, however, such as the sensory transduction of the microtubule cells, do require a specific microtubule substructure. A review of these data is presented in this
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[
Curr Biol,
2016]
Sleeping animals do not move or feed and are less responsive. In Caenorhabditis elegans, a single neuron triggers sleep. A recent study shows that the neuron releases several neuropeptides - each with distinct sleep behavioral effects - to promote the collection of behaviors that is sleep.
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[
Neuron,
2021]
How do organisms without specialized auditory systems perceive and transduce sound? In this issue of Neuron, Iliff etal. (2021) investigate the functional mechanism of airborne sound sensation in Caenorhabditis elegans and highlight the crucial role of alpha-7 nicotinic acetylcholine receptor subunits in mechanotransduction.