The
let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that
let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus,
let-23 might encode the receptor for the inductive signal required for vulval development. Because
let-23 acts upstream of
let-60 ras in the vulval determination pathway, the identification of the
let-23 product provides support for a link in vivo between tyrosine kinase growth factor receptors and ras proteins in a pathway of cell-type determination.AD - Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125.FAU - Aroian, R VAU - Aroian RVFAU - Koga, MAU - Koga MFAU - Mendel, J EAU - Mendel JEFAU - Ohshima, YAU - Ohshima YFAU - Sternberg, P WAU - Sternberg PWLA - engPT - Journal ArticleCY - ENGLANDTA - NatureJID - 0410462RN - 0 (RNA, Messenger)RN - 9007-49-2 (DNA)RN - EC 2.7.1.112 (Protein-Tyrosine Kinase)RN - EC 2.7.11.- (Receptor, Epidermal Growth Factor)SB - IM