Although some RNA-binding proteins are known to contribute to neurodegeneration, the genetic interaction between the genes encoding these proteins is unclear. Here, we examine the interaction between
sym-2, the gene encoding an ortholog of hnRNPF and hnRNPH, and
hrpa-1, the ortholog of of the gene encoding hnRNPA2, which when mutated causes multisystem proteinopathy. We find that after 22 hours, but not 4 hours, of paraquat-induced oxidative stress,
sym-2(
mn617) has a mild glutamatergic neurodegeneration phenotype. Interestingly, this defect is rescued by expression of chimeric WT
hrpa-1, but not mutant. Thus, we identify a curious genetic interaction between
sym-2 and
hrpa-1.