In Caenorhabditis elegans hermaphrodites, physiological germline apoptosis is higher in cdc-25.3
mutants than in wild type. The elevated germline apoptosis in cdc-25.3
mutants seems to be induced by accumulation of double-stranded DNA breaks (DSBs). Both DNA-damage and synapsis checkpoint genes are required to increase the germline apoptosis. Notably, the number of germ cells that lose P-granule components, PGL-1 and PGL-3, increase in cdc-25.3
mutants, and the increase in germline apoptosis requires the activity of SIR-2.1, a Sirtuin ortholog. These results suggest that elevation of germline apoptosis in cdc-25.3
mutants is induced by accumulation of DSBs, leading to a loss of PGL-1 and PGL-3 in germ cells, which promotes cytoplasmic translocation of SIR-2.1, and finally activates the core apoptotic machinery. This article is protected by copyright. All rights reserved.