In nematodes, flies, and mammals, dosage compensation equalizes X-chromosome gene expression between the sexes through chromosome-wide regulatory mechanisms that function in one sex to adjust the levels of X-linked transcripts. Here, a dosage compensation complex was identified in the nematode Caenorhabditis elegans that reduces transcript levels from the two X chromosomes in hermaphrodites. This complex contains at least four proteins, including products of the dosage compensation genes
dpy-26 and
dpy-27. Specific localization of the complex to the hermaphrodite X chromosomes is conferred by XX-specific regulatory genes that coordinately control both sex determination and dosage compensation.AD - Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.FAU - Chuang, P TAU - Chuang PTFAU - Lieb, J DAU - Lieb JDFAU - Meyer, B JAU - Meyer BJLA - engID - GM30702/GM/NIGMSID - T32 GM07127/GM/NIGMSPT - Journal ArticleCY - UNITED STATESTA - ScienceJID - 0404511RN - 0 (Carrier Proteins)RN - 0 (DPY-27 protein)RN - 0 (Helminth Proteins)RN - 0 (Nuclear Proteins)RN - 0 (RNA, Helminth)RN - 0 (RNA, Messenger)SB - IM