[
International Worm Meeting,
2003]
Mammalian hormone-sensitive lipase is the rate-limiting enzyme for hydrolysis of triglycerides and is therefore important for mobilization of stored fat. C46C11.1 encodes a C.elegans homologue to hormone-sensitive lipase and we are interested in its role in energy homeostasis. Using RNAi in different genetic backgrounds the role of C46C11.1 in fat metabolism and other cellular processes was investigated. We will discuss possible underlying molecular mechanisms for observed phenotypes.