[
Science,
1994]
Like people, cells die in different ways: accident, murder, old age, even suicide. In fact, cellular suicide isn't just a curiosity, it's necessary for the health of the organism. During embryonic development, for example, it helps weed out superfluous nerve cells, as well as immune cells that might attack and damage the body's own tissues. Like a spy-plane pilot who carries a little vial of poison under his seat in case he's captured, cells carry in their nuclei a genetic program for suicide that can be set in motion, should the cell receive orders to self-destruct. Now, after years of eluding researchers, the genes that carry out the suicide program are coming into the light...
[
Science,
1996]
Geoffrey Gold, a physiologist at the Monell Chemical Senses Center in Philadelphia, had wanted for years to put to rest a nagging question: How do odors trigger olfactory neurons to fire off action potentials to the brain? The dogma for the past 5 years had been that odors fall into two catagories, each of which acts via a different inracellular messenger molecule. But Gold believed this view was wrong, and that all odors work by increasing the production of the intracellular messenger cyclic AMP (cAMP). One day last spring, Gold got a phone call out of the blue from neurobiologist John Ngai, at the University of California (UC), Berkeley, offering the possibility of answering this question. It was my dream come true," says Gold. ......