In their Brevia "Long-lived C. elegans daf-2
mutants are resistant to bacterial pathogens," D.A. Garsin et al. show that long-lived C. elegans daf-2
mutants are resistant to killing by bacterial pathogens. Partial loss-of-function mutations in daf-2
, which encodes an insulin-like receptor, results in de-repression of the transcription factor daf-16
, leading to life extension and increased resistance to bacterial pathogens Enterococcus faecalis, Staphylococcus aureus, and Pseudomonas aeruginosa.