The inhibition of autophagy with an
atg-13 mutation delays the developmental time of an
rpn-10;
atg-13 mutant compared to the
rpn-10 or
atg-13 mutants and only 80% of worms reach adulthood (n = 283 for WT, = 298 for
rpn-10, = 282 for
atg-13, and = 300 for
rpn-10;
atg-13, p<0.0001 for differences between
atg-13;
rpn-10 and
rpn-10 at the 88 hour time point by Fisher's exact test); Notably, almost 20% of the
rpn-10;
atg-13 mutants appeared to be permanently arrested during development and failed to reach adulthood even after five days