The msra-1 knocked-down worms show decreased motility in the presence of human Amyloid beta transgenic worms, but not alone. The thrashes per minute data is from of 1-day old adult worms.
"We have engineered transgenic Caenorhabditis elegans animals to inducibly express the human beta amyloid peptide (AB). Gene expression changes resulting from AB induction have been monitored by cDNA hybridization to glass slide microarrays containing probes for almost all known or predicted C. elegans genes." [see Table 2]
"We have engineered transgenic Caenorhabditis elegans animals to inducibly express the human beta amyloid peptide (AB). Gene expression changes resulting from AB induction have been monitored by cDNA hybridization to glass slide microarrays containing probes for almost all known or predicted C. elegans genes." [see Table 2]
"We have engineered transgenic Caenorhabditis elegans animals to inducibly express the human beta amyloid peptide (AB). Gene expression changes resulting from AB induction have been monitored by cDNA hybridization to glass slide microarrays containing probes for almost all known or predicted C. elegans genes." [see Table 2]
"We have engineered transgenic Caenorhabditis elegans animals to inducibly express the human beta amyloid peptide (AB). Gene expression changes resulting from AB induction have been monitored by cDNA hybridization to glass slide microarrays containing probes for almost all known or predicted C. elegans genes." [see Table 2]
"We used quantitative RT-PCR to verify a few genes identified by the RNA-seq approach. Three of the four genes tested had a significant difference in mRNA change between the glucose supplemented compared to the OP50 fed (Figure S5)."