"Although not identified in our microarray study,
irg-1 reproducibly increased after
sams-1 RNAi in qRT-PCR experiments, requiring
pmk-1 (Figure 2B). Thus, there may be some regulatory distinctions between low SAM and pathogen exposure. Loss of
pmk-1 did not limit upregulation of lipogenic genes, or
arf-1.1, the gene with the highest-fold increase in
sams-1(RNAi) microarrays (Figure 2C), demonstrating that
pmk-1 is not generally required for transcriptional changes in
sams-1(RNAi) animals"