wdr-23 mRNA levels were over 5-fold greater in
wdr-23(
tm1817) worms than wildtype worms and this elevation was completely dependent on
skn-1.
skn-1(RNAi) blocked induction of both
wdr-23 transgenes by
wdr-23(RNAi), which is consistent with the real-time RT-PCR data. Under basal conditions, the two
wdr-23 variants are broadly expressed. When repression of SKN-1 is removed, both
wdr-23 transcripts are strongly activated by a mechanism that requires
skn-1.