"To confirm that the repression of ELT-2 transcriptional targets by B. pseudomallei is associated with inactivation of
elt-2, we measured the transcript levels of ELT-2 targets in adult worms following
elt-2 knockdown by RNAi and upon BpR15 infection. We observed a more pronounced reduction of ELT-2 transcriptional targets (
asp-3,
mtl-1,
mtl-2,
elo-6, F55G11.2) expression in
elt-2 RNAi-treated adult animals after BpR15 infection (Fig. 2C)."