"In Myotactin (
let-805) mutants, VAB-19::GFP was normally localized to muscle-adjacent regions of the epidermis but never became distributed into circumferential stripes. Within 15-20 minutes of muscle contraction starting (~430 minutes), VAB-19::GFP became dispersed into puncta within epidermal cells (Fig. 6B). Thus, VAB-19 requires Myotactin for its subcellular localization in epidermal cells. By contrast, in
vab-10A(
ju281ts) mutants, VAB-19::GFP remained confined to the regions of epidermal cells overlying muscle (Fig. 6D) but never became localized to attachment structures."