Authors observed that synaptic vesicle (SV) soma accumulations are further increased in the
sam-4 unc- 104
(js901) double mutant relative to either single mutant. Additionally, we found that
sam-4 unc-104(
js901) double mutants exhibit very severe locomotion defects relative to either single mutant, exhibiting defects comparable to severe
unc-104 mutants. These results suggest that SAM-4 functions in concert with the UNC-104 protein to regulate the SV trafficking.