"In the suppressor screen, we utilized pleiotropic defects of
cmk-1 mutants:
cmk-1 mutants showed abnormally low expression of
nhr-38 promoter-fused GFP, an AFD neuron-specific GFP marker (Satterlee et al., 2004). Therefore, we mutagenized
cmk-1 mutants carrying
nhr-38 promoter-fused GFP and found that a mutation in
sur-2 gene that encodes the ortholog of human MED23, a subunit of transcription mediator complex (Singh and Han, 1995), restored the expression of the GFP marker in a
cmk-1 mutant background (Figures S3A and S3B)."