SLO-1::GFP puncta appeared diffuse and dim in the ventral and dorsal nerve cords and were essentially absent in body-wall muscle cells of the dyb-1 mutant.
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The punctate SLO-1::GFP expression pattern in the muscle membrane of wild-type animals was greatly diminished in the muscles of either dys-1 or ctn-1 mutant.
In wild-type animals, SLO-1::GFP is expressed in the muscle membrane in a punctate pattern closely resembling that of dense body localization. We observed a marked reduction of ~75-90% in the intensity of SLO-1::GFP puncta in muscle cells across all DAPC(lf) mutants relative to WT (p<0.001), thereby identifying a common underlying defect in SLO-1 localization resulting from DAPC loss-of-function.
In wild-type animals, SLO-1::GFP is expressed in the muscle membrane in a punctate pattern closely resembling that of dense body localization. We observed a marked reduction of ~75-90% in the intensity of SLO-1::GFP puncta in muscle cells across all DAPC(lf) mutants relative to WT (p<0.001), thereby identifying a common underlying defect in SLO-1 localization resulting from DAPC loss-of-function.