"During embryogenesis, a proportion of the
lag-1(
om13) thermosensitive mutant embryos fail to develop and do not hatch (Qiao et al, 1995). In N2 animals (N2 refers to the WT strain), we observed that the RNAi-induced inactivation of
lin-61 has no incidence on embryonic lethality (Fig EV5). In contrast, in
lag-1(
om13) animals,
lin-61(RNAi) results in a twofold increase of embryonic lethality from 27 to 51%, thus demonstrating a genetic interaction between
lag-1 and
lin-61 during C. elegans embryonic development (Fig EV5)"