"The absence of an induction of the
daf-16 gene suggests that
daf-16 activity might be regulated by AZD2281 and NR via changes in subcellular distribution rather than transcription (Alam et al., 2010). Strikingly, the stress responses were specific for
sod-3 and UPRmt, as expression of cytosolic or ER UPR markers, as well as other antioxidants did not change, or even decrease (Figure 4E)."