"
hmgs-1 RNAi induces strong and robust phenotypes including paralysis, reduced pharyngeal pumping, and sterility (Fig S3B and Movie S1). In agreement with previous reports on the involvement of
hmgs-1 in the mevalonate pathway (26, 27), these
hmgs-1 RNAi phenotypes were fully rescued by mevalonate supplementation, indicating that C. elegans HMGS-1 is functionally equivalent to its ortholog HMGCS1 (Fig S3B and Movie S2)."