"Epistasis analysis was performed with
pry-1(
mu38) and the mutations
bar-1(
ga80) and
mig-14(
ga62), which cause too few VPCs to adopt induced fates. The
ga80 mutation introduces an early stop codon in BAR-1, and is predicted to cause a null mutant phenotype (Eisenmann et al. 1998).
mig-14(
ga62) is a viable, reduction-of-function mutation, which causes defects in multiple Wnt-mediated processes in embryogenesis and post-embryonic life (Eisenmann and Kim 2000). The Overinduced phenotype of
pry-1(
mu38) is still manifest in a double mutant with
mig-14(
ga62), but is strongly reduced in a double mutant with
bar-1(
ga80) (Table 1)." With regard to vulval cell induction,
pry-1(
mu38) is epistatic to
mig-14(
ga62) and
bar-1(
ga80) is epistatic to
pry-1(
mu38).