daf-2 RNAi specifically at the adult stage resulted in a synergistic enhancement of the increased mRNA expression of lipl-4/K04A8.5 induced by the glp-1(e2141) mutation
lipl-4/K04A8.5 RNAi resulted in increased fat content in the glp-1(e2141) mutant background, thereby partially rescuing the reduced fat phenotype of glp-1 mutants
Loss of mir-71 function in animals lacking germ cells resulted in 50% reduction in the levels of K04A8.5. Results suggest that mir-71 promotes germline-mediated longevity by regulating the localization and transcriptional activity of DAF-16.
The expression of enzymes regulating both lipid catabolism (gpdh-2/K11H3.1, lipl-4/K04A8.5 and another predicted lipase/F28H7.3) and lipid anabolism (acs-17/C46F4.2 and fasn-1/F32H2.5) were significantly reduced upon frh-1 RNAi.
The expression of enzymes regulating both lipid catabolism (gpdh-2/K11H3.1, lipl-4/K04A8.5 and another predicted lipase/F28H7.3) and lipid anabolism (acs-17/C46F4.2 and fasn-1/F32H2.5) were significantly reduced upon frh-1 RNAi.