Transcriptional regulation is mediated by the IDE located in the promoters of ftn-1
. The IDE contains two WGATAR sequences that are binding sites for the intestinal specific ELT2 GATA transcription factor. Mutation of either of the WGATAR sequences abolished expression of an ftn-1
::GFP-his reporter showing that ELT-2 is required for ftn-1
transcription under iron sufficient conditions.