Transcriptional regulation is mediated by the IDE located in the promoters of
ftn-1. The IDE contains two WGATAR sequences that are binding sites for the intestinal specific ELT2 GATA transcription factor. Mutation of either of the WGATAR sequences abolished expression of an
ftn-1::GFP-his reporter showing that ELT-2 is required for
ftn-1 transcription under iron sufficient conditions.