lin-35(lf) mutant abrogated the increased apoptosis phenotype induced by misc-1 RNAi. Authors suggest that these results suggest that misc-1 acts through the LIN-35/Rb-mediated physiological pathway of apoptosis.
In the lin-35 (Rb) mutant, PGL-1 is ectopically expressed in intestine, hypoderm and particular cells near the nerve ring, where it accumulates into perinuclear structures that closely resemble the normally germline-restricted P granules.