"Consistently, cell killing by HBx was partially suppressed by either
ced-3(
n2433) or
mec-6(
e1342) lf mutations and eliminated by loss of both genes (Fig. 2A). These results confirm that HBx induces both apoptosis and necrosis in C. elegans." "Loss of
egl-1,
ced-3, or
ced-4 partially suppressed HBx-induced cell death (from 50% to 22-26% PLM death; Fig. 2A), indicating that HBx induces cell death partly through the apoptotic pathway."