wrt-5

Caenorhabditis elegans

Predicted to enable signaling receptor binding activity. Predicted to be involved in cell communication. Predicted to be located in extracellular region. Expressed in several structures, including excretory system; hermaphrodite gonad; pharyngeal-intestinal valve; phasmid socket cell; and rectal valve cell.

wrt-2

Caenorhabditis elegans

Expressed in hypodermal cell and hypodermis.

wrt-9

Caenorhabditis elegans

Expressed in hypodermis.

wrt-6

Caenorhabditis elegans

Predicted to enable peptidase activity. Predicted to be involved in cell-cell signaling; protein autoprocessing; and system development. Predicted to be located in cell surface; extracellular region; and plasma membrane. Expressed in anterior ganglion (ant); hypodermis; and neuronal sheath cell. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; gastrointestinal system cancer (multiple); and glomerulonephritis (multiple). Is an ortholog of human SHH (sonic hedgehog signaling molecule).

wrt-10

Caenorhabditis elegans

Expressed in hypodermis; interfacial epithelial cell; and intestine. Is predicted to encode a protein with the following domain: Phosphorylation site.

wrt-8

Caenorhabditis elegans

Predicted to enable peptidase activity. Predicted to be involved in cell-cell signaling; protein autoprocessing; and system development. Predicted to be located in cell surface; extracellular region; and plasma membrane. Expressed in hyp10; hyp6; hyp7 syncytium; hyp8; and hyp9.

wrt-7

Caenorhabditis elegans

Predicted to be involved in protein autoprocessing. Predicted to be located in extracellular region.

wrt-4

Caenorhabditis elegans

Predicted to enable peptidase activity. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in cell surface; extracellular region; and plasma membrane. Expressed in hyp10; hyp6; hyp7 syncytium; hyp8; and hyp9. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; gastrointestinal system cancer (multiple); and glomerulonephritis (multiple). Is an ortholog of human SHH (sonic hedgehog signaling molecule).

wrt-3

Caenorhabditis elegans

Predicted to be located in extracellular region. Expressed in hermaphrodite distal tip cell; hypodermis; muscle cell; and pharyngeal gland cell.

vha-5

Caenorhabditis elegans

Predicted to enable ATPase binding activity. Involved in several processes, including collagen and cuticulin-based cuticle development; exosomal secretion; and multicellular organismal-level water homeostasis. Located in apical plasma membrane; cell body membrane; and cytoplasmic vesicle. Part of vacuolar proton-transporting V-type ATPase complex. Expressed in several structures, including excretory cell; hypodermis; neuronal sheath cell; pharynx; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3).