Predicted to enable phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in several processes, including cellular component organization; nitrogen compound transport; and regulation of locomotion. Located in synapse. Expressed in tail and ventral cord neurons. Used to study Down syndrome and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease 20 and developmental and epileptic encephalopathy 53. Is an ortholog of human SYNJ1 (synaptojanin 1).
Involved in clathrin-dependent endocytosis and necroptotic process. Located in neuromuscular junction. Expressed in several structures, including coelomocyte; head; hermaphrodite gonad; intestine; and muscle cell. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Is an ortholog of human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2); SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1); and SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3).