- unc-104 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables cytoskeletal protein binding activity; phosphatidylinositol phosphate binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including chemical synaptic transmission; regulation of cellular component organization; and regulation of cellular localization. Located in axon; presynapse; and somatodendritic compartment. Expressed in epithelial cell; muscle cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of the nervous system (multiple); carcinoma (multiple); and neuropathy (multiple). Is an ortholog of human KIF1A (kinesin family member 1A).
- klp-6 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in cytoskeleton-dependent intracellular transport and microtubule-based movement. Located in neuronal cell body and plasma membrane bounded cell projection. Expressed in ciliated neurons; head; tail; and in male. Used to study autosomal dominant polycystic kidney disease. Is an ortholog of human KIF28P (kinesin family member 28, pseudogene).
- ptl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables kinesin binding activity and microtubule binding activity. Involved in microtubule polymerization and positive regulation of nematode male tail tip morphogenesis. Located in axon. Expressed in intestinal muscle; neurons; and tail. Used to study tauopathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease (multiple); and breast cancer. Is an ortholog of human MAP4 (microtubule associated protein 4).
- sam-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including multicellular organismal reproductive process; positive regulation of anterograde synaptic vesicle transport; and positive regulation of pharyngeal pumping. Located in synaptic vesicle membrane. Expressed in nerve ring. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Is an ortholog of human BORCS5 (BLOC-1 related complex subunit 5).
- lnp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metal ion binding activity. Involved in several processes, including regulation of egg-laying behavior; synapse assembly; and synaptic vesicle transport. Located in several cellular components, including neuron projection; neuronal cell body; and synaptic vesicle. Expressed in hypodermis; muscle cell; and neurons. Is an ortholog of human LNPK (lunapark, ER junction formation factor).
- nipa-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable magnesium ion transmembrane transporter activity. Involved in adult locomotory behavior. Located in neuronal cell body. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 6 and hereditary spastic paraplegia 6. Is an ortholog of human NIPAL1 (NIPA like domain containing 1).
- klp-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in cytoskeleton-dependent intracellular transport and microtubule-based movement. Located in axon; cytoplasmic microtubule; and neuronal cell body. Expressed in distal tip cell; dorsal nerve cord; head; and ventral nerve cord. Is an ortholog of human KIF13A (kinesin family member 13A) and KIF13B (kinesin family member 13B).