- spe-41 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables store-operated calcium channel activity. Involved in calcium ion transport; intracellular calcium ion homeostasis; and single fertilization. Located in cytoplasmic vesicle and pseudopodium membrane. Expressed in sperm and spermatid.
- trp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to be located in plasma membrane. Predicted to be part of cation channel complex. Expressed in neurons and non-striated muscle. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including cerebellar ataxia type 41; chronic fatigue syndrome; and focal segmental glomerulosclerosis 2. Is an ortholog of human TRPC3 (transient receptor potential cation channel subfamily C member 3); TRPC6 (transient receptor potential cation channel subfamily C member 6); and TRPC7 (transient receptor potential cation channel subfamily C member 7).
- trp-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and regulation of cytosolic calcium ion concentration. Predicted to be located in plasma membrane. Predicted to be part of cation channel complex. Expressed in ASER; SMDDL; SMDDR; SMDVL; and SMDVR. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1H; lung cancer; and stomach cancer. Is an ortholog of human TRPC4 (transient receptor potential cation channel subfamily C member 4) and TRPC5 (transient receptor potential cation channel subfamily C member 5).
- trp-4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium channel activity. Predicted to be involved in sensory perception of mechanical stimulus. Predicted to be located in membrane. Expressed in dopaminergic neurons; dorsal-rectal ganglion neurons; head mesodermal cell; mechanosensory neurons; and rectum. Is an ortholog of human ANKRD28 (ankyrin repeat domain 28) and ANKRD44 (ankyrin repeat domain 44).
- cup-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable NAADP-sensitive calcium-release channel activity and phosphatidylinositol-3,5-bisphosphate binding activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; determination of adult lifespan; and lysosomal lumen acidification. Located in endolysosome and lysosomal membrane. Expressed in coelomocyte; head; intestinal cell; and neurons. Used to study mucolipidosis type IV. Human ortholog(s) of this gene implicated in glycoproteinosis and mucolipidosis type IV. Is an ortholog of human MCOLN1 (mucolipin TRP cation channel 1); MCOLN2 (mucolipin TRP cation channel 2); and MCOLN3 (mucolipin TRP cation channel 3).
- gtl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable monoatomic cation channel activity. Involved in defecation. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; and congenital stationary night blindness 1C. Is an ortholog of human TRPM1 (transient receptor potential cation channel subfamily M member 1); TRPM3 (transient receptor potential cation channel subfamily M member 3); and TRPM7 (transient receptor potential cation channel subfamily M member 7).