Predicted to enable clathrin adaptor activity. Involved in positive regulation of locomotion. Located in synapse. Expressed in DD neuron; VD neuron; and cholinergic neurons. Is an ortholog of human STON2 (stonin 2).
Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation. Located in membrane raft. Expressed in intestine. Used to study obesity.
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; scaffold protein binding activity; and transcription coactivator activity. Involved in several processes, including cell fate commitment involved in formation of primary germ layer; gonad development; and regulation of gene expression. Located in several cellular components, including cell cortex; kinetochore; and pericentriolar material. Expressed in several structures, including ABplpapaap; ABprpapaap; Z1.aa; posterior distal tip cell; and tail hypodermis.
Enables transcription coactivator binding activity. Involved in regulation of asymmetric cell division. Located in nucleus. Expressed in several structures, including TL.aa; TL.pa; TR.aa; TR.pa; and hypodermal cell.
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including mesodermal cell fate commitment; regulation of cell division; and regulation of gene expression. Located in cytoplasm and nucleus. Expressed in several structures, including ABplpapaaa; ABprpapaaa; oocyte; somatic nervous system; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including diabetes mellitus (multiple); endocrine gland cancer (multiple); and prostate disease (multiple). Is an ortholog of human TCF7L2 (transcription factor 7 like 2).
Enables MAP kinase kinase kinase activity. Involved in several processes, including cell fate commitment; embryonic digestive tract morphogenesis; and signal transduction. Located in striated muscle dense body. Expressed in BAGL and BAGR. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); frontometaphyseal dysplasia 2; and intrinsic cardiomyopathy (multiple). Is an ortholog of human MAP3K7 (mitogen-activated protein kinase kinase kinase 7).
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coactivator activity. Involved in several processes, including nematode larval development; regulation of locomotion; and reproductive behavior. Located in several cellular components, including adherens junction; cytosol; and nucleus. Expressed in several structures, including gonad; intestine; and vulva.
Involved in several processes, including cellular localization; determination of adult lifespan; and first cell cycle pseudocleavage. Located in cell cortex and nucleus. Expressed in head neurons. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); ovarian cancer; and urinary bladder cancer. Is an ortholog of human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta).