Is affected by several genes including pmk-1; tax-6; and ogt-1 based on microarray studies. Is affected by four chemicals including Testosterone; Colistin; and dafa#1 based on microarray studies.
Enriched in body wall muscle cell; dopaminergic neurons; and hypodermis based on tiling array studies. Is affected by several genes including daf-2; eat-2; and tax-6 based on RNA-seq and microarray studies.
Contributes to intracellular cGMP-activated cation channel activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; negative regulation of cGMP-mediated signaling; and positive regulation of macromolecule biosynthetic process. Part of cation channel complex. Expressed in ciliated neurons. Human ortholog(s) of this gene implicated in achromatopsia 3 and retinitis pigmentosa 45. Is an ortholog of human CNGB1 (cyclic nucleotide gated channel subunit beta 1) and CNGB3 (cyclic nucleotide gated channel subunit beta 3).
Enables identical protein binding activity; intracellular cAMP-activated cation channel activity; and intracellular cGMP-activated cation channel activity. Involved in several processes, including detection of stimulus; positive regulation of macromolecule biosynthetic process; and response to temperature stimulus. Located in ciliary inversin compartment; dendrite; and non-motile cilium. Part of cation channel complex. Human ortholog(s) of this gene implicated in achromatopsia 2 and retinitis pigmentosa 49. Is an ortholog of human CNGA1 (cyclic nucleotide gated channel subunit alpha 1) and CNGA2 (cyclic nucleotide gated channel subunit alpha 2).
Enriched in male based on RNA-seq studies. Is affected by several genes including tph-1; csr-1; and tax-6 based on RNA-seq and microarray studies. Is affected by five chemicals including Zidovudine; allantoin; and Sirolimus based on RNA-seq studies.
Enables calcium ion binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including determination of adult lifespan; male mating behavior; and response to temperature stimulus. Located in several cellular components, including neuronal cell body; nucleus; and plasma membrane bounded cell projection. Expressed in several structures, including germ line; head neurons; muscle cell; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including aortic valve stenosis; cholangiocarcinoma; and developmental and epileptic encephalopathy 91. Is an ortholog of human PPP3CB (protein phosphatase 3 catalytic subunit beta) and PPP3CC (protein phosphatase 3 catalytic subunit gamma).
Enables calcium ion binding activity. Predicted to be involved in calcineurin-mediated signaling. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Expressed in several structures, including germ line; gonad; muscle cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Is an ortholog of human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha).
Enables guanylate cyclase activity. Involved in microvillus organization and response to temperature stimulus. Located in microvillus membrane and neuron projection terminus. Expressed in AFDL and AFDR.
Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in detection of temperature stimulus; thermosensory behavior; and thermotaxis. Located in neuron projection terminus. Expressed in AFDL and AFDR.