Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in maintenance of presynaptic active zone structure; spontaneous synaptic transmission; and synaptic vesicle cycle. Located in presynaptic active zone. Expressed in nervous system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Is an ortholog of human BSN (bassoon presynaptic cytomatrix protein) and PCLO (piccolo presynaptic cytomatrix protein).
Is an ortholog of C. elegans cla-1. In C. elegans, cla-1 is involved in maintenance of presynaptic active zone structure; spontaneous synaptic transmission; and synaptic vesicle cycle.
Predicted to be located in endoplasmic reticulum membrane. Expressed in head; neurons; spermatheca; and vulva. Is an ortholog of human TMEM41B (transmembrane protein 41B).
Predicted to be involved in negative regulation of apoptotic signaling pathway. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane. Expressed in excretory system; neurons; and pharyngeal muscle cell. Is an ortholog of human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1).
Involved in regulation of gene expression. Expressed in excretory cell; hypodermis; pharynx; somatic nervous system; and tail neurons. Used to study Parkinson's disease.