Enables sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; pharyngeal muscle development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including G1; gonad; neurons; pharyngeal cell; and ventral nerve cord. Used to study cancer. Is an ortholog of human NKX2-2 (NK2 homeobox 2).
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; scaffold protein binding activity; and transcription coactivator activity. Involved in several processes, including cell fate commitment involved in formation of primary germ layer; gonad development; and regulation of gene expression. Located in several cellular components, including cell cortex; kinetochore; and pericentriolar material. Expressed in several structures, including ABplpapaap; ABprpapaap; Z1.aa; posterior distal tip cell; and tail hypodermis.
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process and leucine catabolic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).