Is an ortholog of human MAP3K15 (mitogen-activated protein kinase kinase kinase 15). Exhibits MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein kinase activator activity. Is involved in several processes, including defense response to other organism; p38
MAPK cascade; and positive regulation of MAP kinase activity. Localizes to the axon cytoplasm; neuronal cell body; and postsynaptic density. Is expressed in head; rectal gland cell; and tail. Is used to study amphetamine abuse.