- ubr-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in carcinoma (multiple) and invasive ductal carcinoma. Is an ortholog of human UBR5 (ubiquitin protein ligase E3 component n-recognin 5).
- sog [Search on AGR]
Drosophila melanogaster short gastrulation (sog) encodes a secreted BMP antagonist that is expressed in the embryonic ventral neuroectoderm. sog product promotes neural development by preventing dorsally produced dpp from diffusing into the neuroectoderm and suppressing expression of neural genes. sog protein also diffuses dorsally where it helps establish a BMP activity gradient essential for partitioning that domain into cells giving rise to the dorsal epidermis versus amnioserosa.
- tsg [Search on AGR]
Drosophila melanogaster twisted gastrulation (tsg) encodes a BMP binding protein that makes a tripartite complex with the product of sog and a heterodimer formed with the products of dpp and scw. This complex is a favoured substrate for the product of tld, which processes the product of sog and liberates the heterodimer formed with the products of dpp and scw.
- tok [Search on AGR]
Drosophila melanogaster tolkin (tok) encodes a Zinc metallopeptidase with similar substrate specificity to the product of tld, which is its paralog. It cleaves the product of sog as well as the prodomains of several TGF-beta ligands.
- nas-39 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metalloendopeptidase activity. Predicted to be involved in dorsal/ventral pattern formation and protein processing. Predicted to be located in extracellular space. Expressed in neurons and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in atrial heart septal defect 6; coronary artery disease; and osteogenesis imperfecta type 13. Is an ortholog of human BMP1 (bone morphogenetic protein 1) and TLL2 (tolloid like 2).
- tld [Search on AGR]
Drosophila melanogaster tolloid (tld) encodes a member of the asticin metalloprotease family. Its primary function is to cleave the product of sog, which facilitates the diffusion of the ligand encoded by dpp to the dorsal-most cells in the early blastoderm embryo, helping to specify formation of the amnioserosa.