Enables enzyme binding activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be located in cytoplasm. Predicted to be part of exon-exon junction complex and polysome. Is an ortholog of human UPF2 (UPF2 regulator of nonsense mediated mRNA decay).
Enables DEAD/H-box RNA helicase binding activity and protein phosphatase 2A binding activity. Involved in embryonic genitalia morphogenesis; ncRNA metabolic process; and negative regulation of gene expression. Located in cytoplasm and nucleus.
Is affected by several genes including rrf-3; set-2; and smg-2 based on RNA-seq studies. Is affected by antimycin; CGP37157; and paraquat based on RNA-seq studies.
Predicted to enable protein serine/threonine kinase activity. Involved in male genitalia development; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and obsolete hermaphrodite genitalia development. Predicted to be located in nucleus. Predicted to be part of TORC1 complex and TORC2 complex. Is an ortholog of human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase).
Enriched in AQR; PQR; and sensory neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including clk-1; drh-3; and smg-2 based on microarray and RNA-seq studies.
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytoplasm and ribosome. Predicted to be part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2D. Is an ortholog of human RPL3 (ribosomal protein L3).