tag-68 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable I-SMAD binding activity and transcription regulator inhibitor activity. Predicted to be involved in several processes, including SMAD protein signal transduction; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Expressed in head neurons; intestine; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including aortic valve disease 2; idiopathic pulmonary fibrosis; and liver disease (multiple). Is an ortholog of human SMAD6 (SMAD family member 6) and SMAD7 (SMAD family member 7).