- slo-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables calcium-activated potassium channel activity and outward rectifier potassium channel activity. Involved in positive regulation of neurotransmitter secretion and potassium ion transport. Located in axon. Expressed in amphid neurons; body wall musculature; motor neurons; nerve ring; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5; developmental and epileptic encephalopathy 14; and developmental and epileptic encephalopathy 57. Is an ortholog of human KCNT1 (potassium sodium-activated channel subfamily T member 1) and KCNT2 (potassium sodium-activated channel subfamily T member 2).
- slo-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables calcium-activated potassium channel activity and voltage-gated potassium channel activity. Involved in several processes, including behavioral response to ethanol; pharyngeal pumping; and sarcomere organization. Located in M band; striated muscle dense body; and synapse. Expressed in several structures, including AWC; body wall musculature; non-striated muscle; pharyngeal neurons; and somatic nervous system. Used to study Duchenne muscular dystrophy and alcohol use disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; idiopathic generalized epilepsy; paroxysmal nonkinesigenic dyskinesia 3; and spermatogenic failure. Is an ortholog of human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).
- eif-1.A [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Expressed in head and tail. Is an ortholog of human EIF1AX (eukaryotic translation initiation factor 1A X-linked) and EIF1AY (eukaryotic translation initiation factor 1A Y-linked).
- bkip-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables transmembrane transporter binding activity. Located in neuron projection and striated muscle dense body. Expressed in body wall musculature; head mesodermal cell; muscle cell; neurons; and somatic nervous system.
- eef-1A.1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables GTPase activity. Predicted to be involved in translational elongation. Predicted to be located in cytoplasm. Expressed in hypodermis; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant intellectual developmental disorder 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Is an ortholog of human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1); EEF1A1P5 (eukaryotic translation elongation factor 1 alpha 1 pseudogene 5); and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2).
- icln-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be involved in mRNA cis splicing, via spliceosome and spliceosomal snRNP assembly. Predicted to be located in cytosol. Predicted to be part of pICln-Sm protein complex and spliceosomal complex. Is an ortholog of human CLNS1A (chloride nucleotide-sensitive channel 1A).