- lag-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables Notch binding activity. Involved in several processes, including maintenance of dauer; regulation of basement membrane organization; and regulation of cell population proliferation. Located in cell projection membrane and neuronal cell body membrane. Expressed in several structures, including distal tip cell; germ line; hypodermal cell; neurons; and vulval cell.
- mdt-29 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Involved in lateral inhibition; positive regulation of Notch signaling pathway; and regulation of cell fate specification. Predicted to be located in nucleus. Predicted to be part of mediator complex. Expressed in body wall musculature.
- sel-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable endopeptidase activity. Involved in several processes, including apical protein localization; egg-laying behavior; and regulation of signal transduction. Located in perinuclear region of cytoplasm. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 3; Alzheimer's disease 4; Pick's disease; dilated cardiomyopathy (multiple); and hidradenitis suppurativa. Is an ortholog of human PSEN1 (presenilin 1) and PSEN2 (presenilin 2).
- sel-7 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in several processes, including lateral inhibition; negative regulation of transcription by RNA polymerase II; and positive regulation of Notch signaling pathway. Located in nucleus. Expressed in body wall musculature; pharyngeal muscle cell; and seam cell.
- hop-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable endopeptidase activity. Involved in several processes, including egg-laying behavior; positive regulation of Notch signaling pathway; and regulation of vulval development. Predicted to be located in several cellular components, including apical plasma membrane; cytoplasm; and plasma membrane bounded cell projection.
- sel-11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable metal ion binding activity and transferase activity. Involved in regulation of Notch signaling pathway and regulation of gene expression. Predicted to be located in cytoplasm. Is an ortholog of human SYVN1 (synoviolin 1).
- sel-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor binding activity; Notch binding activity; and transcription coactivator activity. Involved in several processes, including Notch signaling pathway; positive regulation of stem cell proliferation; and regulation of mesodermal cell fate specification. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and neurons.
- sel-10 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein homodimerization activity and protein kinase binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of centrosome duplication; and regulation of vulval development. Located in axon and cytoplasm. Expressed in body wall musculature; gonad; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Is an ortholog of human FBXW7 (F-box and WD repeat domain containing 7).
- sel-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to contribute to ubiquitin-protein transferase activity. Involved in negative regulation of Notch signaling pathway. Located in cytoplasmic vesicle. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P7.p hermaphrodite; and P8.p hermaphrodite. Human ortholog(s) of this gene implicated in pancreatic cancer. Is an ortholog of human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).