encodes a Rab small GTPase; aex-6
was identified in screens for defecation defective mutants and high-temperature-induced dauer formation mutants; aex-6
appears to act in the insulin branch of the dauer pathway; aex-6
is genetically required for two different steps of normal defecation in the hermaphrodite digestive tract; since its mutant phenotype resembles that induced by ablation of the interneuron AVL and the motor neuron DVB, aex-6
is likely to be required for the function or activation of these neurons rather than for any of their specific neurotransmitter systems; aex-6
::gfp reporter fusions are expressed in neurons and in the intestine; in the nervous system, AEX-6 localizes to synapse-rich regions and partially colocalizes with synaptic vesicle-associated RAB-3.