Enables ATP hydrolysis activity and identical protein binding activity. Involved in several processes, including ER-associated misfolded protein catabolic process; determination of adult lifespan; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleoplasm and perinuclear region of cytoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. Expressed in several structures, including body wall musculature; germ line; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; frontotemporal dementia and/or amyotrophic lateral sclerosis-6; and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1. Is an ortholog of human VCP (valosin containing protein).
Involved in nematode male tail tip morphogenesis and transforming growth factor beta receptor signaling pathway. Located in nucleus. Expressed in hyp7 syncytium; intestine; pharynx; ray; and socket cell.
Predicted to enable copper ion transmembrane transporter activity. Predicted to be involved in copper ion transmembrane transport. Predicted to be located in late endosome membrane. Is an ortholog of human SLC31A1 (solute carrier family 31 member 1) and SLC31A2 (solute carrier family 31 member 2).
Predicted to enable hormone activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Expressed in coelomocyte; male gonad; and seminal vesicle.
Enables double-stranded DNA binding activity. Involved in defense response to Gram-negative bacterium; defense response to fungus; and killing of cells of another organism. Predicted to be located in extracellular region. Expressed in hypodermis.