Enables myosin II tail binding activity; protein serine/threonine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cell fate commitment; embryonic pattern specification; and vulval development. Located in P granule and cell cortex. Expressed in germ line and vulva. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Is an ortholog of human MARK1 (microtubule affinity regulating kinase 1).
par-1 (par-1) encodes a protein kinase involved in multiple processes, including microtubule cytoskeleton organization, axis specification and cell polarity. It regulates hippo signaling and osk mRNA localization.
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 15. Is an ortholog of human EPRS1 (glutamyl-prolyl-tRNA synthetase 1).
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans par-1. In C. elegans, par-1 is involved in several processes, including cell fate commitment; embryonic pattern specification; and vulval development.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans par-1. In C. elegans, par-1 is involved in several processes, including cell fate commitment; embryonic pattern specification; and vulval development.
Predicted to enable ATP binding activity and protein kinase activity. Is an ortholog of C. elegans par-1. In C. elegans, par-1 is involved in several processes, including cell fate commitment; embryonic pattern specification; and vulval development.