Predicted to enable dynein light intermediate chain binding activity and minus-end-directed microtubule motor activity. Involved in several processes, including dauer entry; non-motile cilium assembly; and positive regulation of dauer larval development. Located in non-motile cilium. Expressed in I4 neuron; PDEL; PDER; and nerve ring. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 3. Is an ortholog of human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1).
Predicted to enable Notch binding activity. Involved in regulation of gene expression and response to osmotic stress. Predicted to be located in extracellular space. Expressed in hypodermis.
Is affected by several genes including daf-2; pgl-1; and osm-3 based on RNA-seq and microarray studies. Is affected by Colistin and triclosan based on microarray studies.
Involved in chemotaxis; cilium organization; and protein localization to microvillus membrane. Located in ciliary basal body; neuron projection; and non-motile cilium. Expressed in ciliated neurons and sensory neurons. Used to study Bardet-Biedl syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 7. Is an ortholog of human BBS7 (Bardet-Biedl syndrome 7).
Enables Notch binding activity. Involved in several processes, including positive regulation of Notch signaling pathway; response to osmotic stress; and vulval development. Located in apical part of cell and extracellular space. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and hermaphrodite gonad.
Is affected by several genes including daf-2; prg-1; and osm-3 based on RNA-seq and microarray studies. Is affected by five chemicals including Hydrolyzable Tannins; Colistin; and dafa#1 based on microarray studies.
Involved in dauer entry and non-motile cilium assembly. Located in ciliary transition zone and non-motile cilium. Part of intraciliary transport particle B. Expressed in amphid neurons; ciliated neurons; phasmid neurons; and sensory neurons. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 20; retinitis pigmentosa 71; and short-rib thoracic dysplasia 10 with or without polydactyly. Is an ortholog of human IFT172 (intraflagellar transport 172).
Involved in several processes, including non-motile cilium assembly; response to osmotic stress; and sensory perception of mechanical stimulus. Located in cilium; cytoplasm; and neuronal cell body. Expressed in neurons. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Is an ortholog of human IFT52 (intraflagellar transport 52).