Involved in several processes, including determination of adult lifespan; male mating behavior; and non-motile cilium assembly. Located in cilium. Expressed in ciliated neurons; cloacal ganglion; postcloacal sensillum; and sensory neurons. Used to study nephronophthisis. Human ortholog(s) of this gene implicated in several diseases, including Joubert syndrome 4; Senior-Loken syndrome; and nephronophthisis 1. Is an ortholog of human NPHP1 (nephrocystin 1).
Involved in several processes, including determination of adult lifespan; larval foraging behavior; and non-motile cilium assembly. Located in ciliary basal body; ciliary transition zone; and dendrite terminus. Expressed in neurons. Used to study Joubert syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome. Is an ortholog of human B9D2 (B9 domain containing 2).
Expressed in neurons. Used to study Meckel syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 13; Joubert syndrome 28; and Meckel syndrome 1. Is predicted to encode a protein with the following domains: Ciliary basal body-associated, B9 protein and B9-type C2 domain. Is an ortholog of human MKS1 (MKS transition zone complex subunit 1).
Involved in several processes, including determination of adult lifespan; larval foraging behavior; and non-motile cilium assembly. Located in ciliary transition zone. Expressed in amphid neurons; ciliated neurons; and sensory neurons. Used to study ciliopathy and nephronophthisis. Human ortholog(s) of this gene implicated in Joubert syndrome 27 and Meckel syndrome. Is an ortholog of human B9D1 (B9 domain containing 1).