Predicted to enable cholesterol binding activity. Involved in several processes, including cholesterol homeostasis; positive regulation of growth rate; and regulation of egg-laying behavior. Predicted to be located in late endosome; lysosome; and plasma membrane. Expressed in several structures, including excretory cell; head neurons; hypodermis; lumbar neurons; and pharynx. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Is an ortholog of human NPC1 (NPC intracellular cholesterol transporter 1).
Predicted to enable cholesterol binding activity. Involved in cholesterol homeostasis; cholesterol transport; and nematode larval development. Predicted to be located in plasma membrane. Expressed in XXXL; XXXR; gonadal sheath cell; spermatheca; and ventral nerve cord. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Is an ortholog of human NPC1 (NPC intracellular cholesterol transporter 1).